Terbifin 1% Cream 5 gm
৳ 80
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About the Product
Full Description
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\nTerbinafine hydrochloride is a synthetic allylamine antifungal, which is fungicidal against dermatophytes, mold fungi and some yeasts. Terbinafine interferes with fungal ergosterol biosynthesis by inhibiting squalene epoxidase in the cell membrane. This leads to a deficiency of ergosterol and an intracellular accumulation of squalene, thus disrupting fungal membrane function and cell wall synthesis resulting in fungal cell death. Terbinafine does not inhibit cytochrome P450 activity and is weakly bound to hepatic cytochrome P450 enzymes. Terbinafine is distributed into the stratum corneum of the skin, the nail plate and hair in higher concentration than found in plasma.
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\nPresentation:
\nTerbifin Tablet: Each tablet contains Terbinafine Hydrochloride INN equivalent to Terbinafine 250 mg. Terbifin Cream: Each gram contains Terbinafine Hydrochloride INN 10 mg.
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\nIndication:
\nTerbifin Tablet: Dermatophyte infections of the nails, ringworm infections (including tinea pedis, crusis and corporis) where oral therapy is appropriate (due to site, severity and extent). Terbifin Cream: Dermatophyte infections of the skin and hair, pityriasis (tinea) versicolor and yeast infections of the skin. Other uses: >Non-dermatophyte nail infections >Systemic mycoses with dimorphic and rare mold fungi.
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\nDosage & Administration:
\nTerbifin Tablet: Child: Usually for 2 weeks, tinea capitis, over 1 year, body-weight 10-20kg, 62.5 mg once daily; body-weight 20-40kg, 125 mg once daily; body-weight over 40 kg, 250 mg once daily. Terbifin Cream: Applied once or twice daily in: Application of Terbifin Cream: Clean and dry the affected areas thoroughly before application of Terbifin. Apply the cream to the affected skin and surrounding area in a thin layer and rub it lightly. In case of intertriginous infections (submammary, interdizital, intergluteal, inguinal) the application may be covered with a gauze strip, especially at night. Wash the hands thoroughly after application.
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\nContrainidications:
\nHypersensitivity to terbinafine or any of the excipients contained in the tablet or cream.
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\nWarning & Precautions:
\nTerbifine cream is for external use only. Contact with eyes should be avoided.Good general hygiene is necessary in conjunction with the use of Terbinafine in order to prevent reinfection (eg. from underwear, socks,shoes etc).
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\nSide effects:
\nTerbifin Tablet: Abdominal discomfort, anorexia, nausea, diarrhoea, headache, rash and urticaria occasionally with arthralgia or myalgia. Less frequently taste disturbance. Rarely liver toxicity, photosensitivity, serious skin reactions etc. Terbifin Cream: Redness, itching, or stinging; rarely allergic reactions.
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\nDrug interaction:
\nTerbifin Tablet: Plasma concentration of terbinafine is increased by Rifampicin. Plasma concentration of terbinafine is decreased by Cimetidine.
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\nUse in special groups:
\nUse in pregnancy and lactation: Pregnancy category B. Treatment with Terbinafine is not recommended in nursing mothers. Use in Children: Terbifine cream appears to be an effective and well-tolerated treatmenr of tinea corposis and tinea cruris in children. Use in Elderly: Terbinafine appears to be safe in the elderly. The dose should be reduced by half if significant hepatic or renal impairment is present.
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\nPacking:
\nTerbifin Tablet: Each box contains 12’s tablets in alu-alu blister pack. Terbifin Cream: Each tube contains 5g cream.
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