Ketoconazole is a synthetic imidazole antifungal agent.
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Indications:
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Systemic mycosis, oral candidiasis, dandruf Pityriasis versicolor etc.
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Mode of Action:?
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Ketoconazole inhibits the fungal cytochrome P ? so enzyme 14-demethylase that inhibits the biosynthesize ergosterol in fungi and changes the composition of other components in the membrane resulting in fungal cell necrosis.