Tablet Flamyd 500 - mg
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About the Product
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\nFlamyd 250: Each film coated tablet contains Metronidazole BP 250 mg.
\nFlamyd 500: Each film coated tablet contains Metronidazole BP 500 mg.
\nFlamyd Gel: Each 1g gel contains Metronidazole BP 7.5 mg.
\nFlamyd IV: Each 100 ml solution contains Metronidazole BP 500 mg.
\nFlamyd Suspension: Each 5 ml suspension contains Metronidazole Benzoate BP equivalent to Metronidazole 200 mg.
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\nDescription
\nMetronidazole is a member of the imidazole class of antibacterial agents and is classified therapeutically as an antiprotozoal and antibacterial agent. The intracellular targets of action of metronidazole on anaerobes are largely unknown. The 5-nitro group of metronidazole is reduced by metabolically active anaerobes, and studies have demonstrated that the reduced form of the drug interacts with bacterial DNA. However, it is not clear whether interaction with DNA alone is an important component in the bactericidal action of metronidazole on anaerobic organisms.
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\nIndications
\nFlamyd tablet
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\n1. The prevention of post-operative infections due to anaerobic bacteria, particularly species of bacteroides and anaerobic streptococci.
\n2. The treatment of septicaemia, bacteraemia, peritonitis, brain abscess, necrotising pneumonia, osteomyelitis, puerperal sepsis, pelvic abscess, pelvic cellulitis and post-operative wound infections from which pathogenic anaerobes have been isolated.
\n3. Urogenital trichomoniasis in the female (trichomonal vaginitis) and in the male.
\n4. Bacterial vaginosis (also known as non-specific vaginitis, anaerobic vaginosis or Gardnerella vaginitis).
\n5. All forms of amoebiasis (intestinal and extra-intestinal disease and that of symptomless cyst passers).
\n6. Giardiasis.
\n7. Acute ulcerative gingivitis.
\n8. Anaerobically-infected leg ulcers and pressure sores.
\n9. Acute dental infections due to anaerobic organisms (eg. acute pericoronitis and acute apical infections).
\n10. H. pylori infection
\n11. Antibiotic Associated Pseudomembranus colitis
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\nFlamyd Gel
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\nBacterial vaginosis (also known as non-specific vaginitis, anaerobic vaginosis or Gardnerella vaginitis).
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\nFlamyd IV Infusion
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\n1. The prevention of postoperative infections due to anaerobic bacteria
\n2. The treatment of septicaemia, bacteraemia, peritonitis, brain abscess, necrotising pneumonia, osteomyelitis, puerperal sepsis, pelvic abscess, pelvic cellulitis, and post-operative wound infections from which pathogenic anaerobes have been isolated.
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\nDosage & Administration
\nTablet and Suspension
\nAmoebic dysentery: Duration 5-10 Days;
\nFor Tablet: Adults- 750 mg t.i.d. Children- (7-10 years) 500 mg t.i.d. (3-7 years) 250 mg q.i.d. (1-3 years) 250 mg t.i.d.
\nFor Suspension: Adults- 800 mg t.i.d. Children- (7-10 years) 500 mg t.i.d. (3-7 years) 200 mg q.i.d. (1-3 years) 200 mg t.i.d.
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\nAsymptomatic amoebiasis: Duration 5-10 Days;
\nFor Tablet: Adults- 500-750 mg t.i.d. Children- (7-10 years) 250-500 mg t.i.d. (3-7 years) 250 mg q.i.d. (1-3 years) 250 mg t.i.d.
\nFor Suspension: Adults- 500-800 mg t.i.d. Children- (7-10 years) 200-500 mg t.i.d.; (3-7 years) 200 mg q.i.d.; (1-3 years) 200 mg t.i.d.
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\nHepatic extraintestinal amoebiasis : Duration 5-10 Days (or 2days);
\nFor Tablet: Adults- 500-750 mg t.i.d.; Children- (7-10 years) 250-500 mg t.i.d.; (3-7 years) 250 mg q.i.d.; (1-3 years) 250 mg t.i.d.
\nFor Suspension: Adults- 500-800 mg t.i.d.; Children- (7-10 years) 200-500 mg t.i.d.; (3-7 years) 200 mg q.i.d.; (1-3 years) 200 mg t.i.d.
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\nGiardiasis: Duration 3 Days;
\nFor Tablet: Adults- 2 g once daily; Children-(7-10 years) 1g once daily; (3-7 years) 750 mg once daily; (1-3 years) 500 mg once daily.
\nFor suspension: Adults- 2 g once daily; Children-(7-10 years) 1g once daily; (3-7 years) 800 mg once daily; (1-3 years) 500 mg once daily.
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\nTrichomoniasis: Duration 7 Days;
\nFor Tablet: Adults- 250 mg t.i.d.; Children- (7-10 years) 100 mg t.i.d.; (3-7 years) 100 mg b.i.d.; (1-3 years) 50 mg t.i.d.
\nFor Suspension: Adults- 200 mg t.i.d.; Children- (7-10 years) 100 mg t.i.d.; (3-7 years) 100 mg b.i.d.; (1-3 years) 50 mg t.i.d.
\nOr,
\nDuration 1 Day;
\nFor Tablet: Adults- 2 g single dose;
\nFor Suspension: Adults- 2 g single dose;
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\nVincent's infection (Ulceration of mucous membrane of respiratory tract & mouth): Duration 3 Days;
\nFor Tablet: Adults- 250 mg t.i.d. or 500 mg b.i.d; Children- (7-10 years) 100 mg t.i.d.; (3-7 years) 100 mg b.i.d.; (1-3 years) 50 mg t.i.d.
\nFor Suspension: Adults- 200 mg t.i.d. or 500 mg b.i.d; Children- (7-10 years) 100 mg t.i.d.; (3-7 years) 100 mg b.i.d.; (1-3 years) 50 mg t.i.d.
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\nPeriodontal infection: Duration 3 Days;
\nFor Tablet: Adults- 250 mg t.i.d.; Children- (7-10 years) 100 mg t.i.d.; (3-7 years) 100 mg b.i.d.; (1-3 years) 50 mg t.i.d.
\nFor Suspension: Adults- 200 mg t.i.d.; Children- (7-10 years) 100 mg t.i.d.; (3-7 years) 100 mg b.i.d.; (1-3 years) 50 mg t.i.d.
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\nSevere dental infection: Duration 3 Days;
\nFor Tablet: Adults- 500 mg t.i.d.; Children- (7-10 years) 100 mg t.i.d.; (3-7 years) 100 mg b.i.d.; (1-3 years) 50 mg t.i.d.
\nFor Suspension: Adults- 500 mg t.i.d.; Children- (7-10 years) 100 mg t.i.d.; (3-7 years) 100 mg b.i.d.; (1-3 years) 50 mg t.i.d.
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\nAnaerobic infection: Duration 7 Days;
\nFor Tablet: Adults- 500 mg t.i.d.; Children- 7.5 mg/kg body weight t.i.d.
\nFor Suspension: Adults- 500 mg t.i.d.; Children- 7.5 mg/kg body weight t.i.d.
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\nPostoperative anaerobic infection (specially in operation abdominal or gynecological surgery): Duration 7 Days;
\nFor Tablet: Adults- 500 mg t.i.d. before and after operation; Children- 7.5 mg/kg body weight t.i.d.
\nFor Suspension: Adults- 500 mg t.i.d. before and after operation; Children- 7.5 mg/kg body weight t.i.d.
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\nBacterial vaginitis: Duration 7 Days;
\nFor Tablet: Adults- 500 mg b.i.d.
\nFor Suspension: Adults- 500 mg b.i.d.
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\nLeg ulcers: Duration 1 Day;
\nFor Tablet: Adults- 2 g as a single dose
\nFor Suspension: Adults- 2 g as a single dose
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\nPressure sores: Duration 7 Days;
\nFor Tablet: Adults- 500 mg t.i.d.
\nFor Suspension: Adults- 500 mg t.i.d.
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\nH. pylori infection: Duration 7 Days;
\nFor Tablet: Adults- 500 mg b.i.d
\nFor Suspension: Adults-500 mg b.i.d
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\nAntibiotic Associated Pseudomembranus colitis: Duration 7 Days;
\nFor Tablet: Adults- 500 mg b.i.d
\nFor Suspension: Adults- 500 mg b.i.d
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\nFlamyd Gel
\nThe recommended dose is one applicator full of FLAMYD GEL (approximately 5 grams containing approximately 37.5 mg of Metronidazole) intravaginally once or twice a day for 5 days. For once a day dosing, FLAMYD GEL should be administered at bedtime.
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\nFlamyd IV Infusion
\nFlamyd injection should be infused intravenously at an approximate rate of 5 ml/min. Oral medication should be substituted as soon as feasible. Treatment for 7 days should be satisfactory for most patients, but the physician might decide to prolong treatment.
\nFor bacterial infections: Adults: 500 mg (100 ml) 8 hourly. Children: 7.5 mg/kg (1.5 ml/kg) 8 hourly.
\nFor treatment before and during surgery: Adults: 500 mg (100 ml) shortly before operation, repeated 8 hourly. Children: 7.5 mg/kg (1.5 ml/kg) 8 hourly
\nSide Effects
\nPain, tenderness, redness, or swelling over vein in which the medicine is given. Other side-effects are unsteadiness, fever or chills, sore throat, headache, numbness, tingling pain or weakness in the hands or feet, pain, seizures, skin itching, unusual tiredness or weakness, vaginal irritation or discharge.
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\nPrecautions
\nMetronidazole should be given with caution in the following conditions- anaemia or other blood disorders, liver disease, disease of the nervous system, seizures etc.
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\nUse in Pregnancy & Lactation
\nMetronidazole is pregnancy category B. Metronidazole has not been shown to cause birth defects in animal studies; however, use is not recommended during the first trimester of pregnancy. Use is not recommended in nursing mothers since metronidazole passes into the breast milk.
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\nCommercial Pack
\nFlamyd 250: Each box contains 10 blister strips of 10 film coated tablets.
\nFlamyd 500: Each box contains 10 blister strips of 10 film coated tablets.
\nFlamyd Gel: Flamyd Gel (Metronidazole BP 0.75% vaginal gel) is supplied in a 30 gram tube and packaged with a 5 g vaginal applicator.
\nFlamyd IV: Each box contains 1 bag of 100 ml solution for intravenous infusion.
\nFlamyd Suspension: Each bottle contains 60 ml Metronidazole Benzoate suspension.
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