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Composition :
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\nTablet 200 : Metronidazole BP 200 mg.
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\nTablet 400 : Metronidazole BP 400 mg.
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\nSuspension : Metronidazole 200 mg / 5 ml.
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\nSuppository : Metronidazole BP 500 mg.
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\nIV Infusion : Metronidazole BP 500 mg / 100 ml (5 mg /ml).
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Indication :
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\nAmebiasis, urogenital trichomoniasis (both symptomatic and asymptomatic), giardiasis, anaerobic infections, acute ulcerative gingivitis, intra-abdominal infections (peritonitis, intra-abdominal abscess and liver abscess), skin infections, gynaecological infections (endometritis, endomyometritis, tubo-ovarian abscess and post-surgical vaginal cuff infection), bacterial septicaemia, bone and joint infections, CNS infections (meningitis and brain abscess), lower respiratory tract infections (pneumonia, empyema and lung abscess), endocarditis, leg ulcer and pressure sores, prophylaxis of colorectal and pelvic surgery and eradication of Helicobacter pylori in triple therapy with Amoxycillin and Ranitidine.
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Dosage & Administration :?For Tablets and Suspension :
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\n| Indications |
\nDuration of treatment in days |
\nAdults and Children over 10 Years |
\nChildren |
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\n| 7-10 years |
\n3-7 years |
\n1-3 years |
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\n| Invasive intestinal amebiasis |
\n5-10 |
\n800 mg thrice daily |
\n400 mg thrice daily |
\n200 mg four times daily |
\n200 mg thrice daily |
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\n| Asymptomatic amebiasis |
\n5-10 |
\n400-800 mg thrice daily |
\n200-400 mg thrice daily |
\n100-200 mg four times daily |
\n100-200 mg thrice daily |
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\n| Hepatic and extra intestinal Amebic dysentery |
\n5-10 |
\n400-800 mg thrice daily |
\n200-400 mg thrice daily |
\n100-200 mg four times daily |
\n100-200 mg thrice daily |
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\n| Giardiasis |
\n3 |
\n2 g once daily |
\n1 g once daily |
\n600-800 mg once daily |
\n500 mg once daily |
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\n| Trichomoniasis (both the consorts should be treated simultaneously) |
\n7 |
\n200 mg thrice daily
\nor 400 mg twice daily |
\n100 mg thrice daily |
\n100 mg thrice daily |
\n50 mg thrice daily |
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\n2 |
\n800 mg in the morning and 1.2 g at night |
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\n| 1 |
\nSingle dose of 2 g |
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\n| Bacterial vaginosis |
\n7 |
\n400 mg twice daily |
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\n1 |
\nSingle dose of 2 g |
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\n| Acute ulcerative gingivitis |
\n3-7 |
\n200 mg thrice daily |
\n100 mg thrice daily |
\n100 mg twice daily |
\n50 mg thrice daily |
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\n| Leg ulcer and pressure sores |
\n7 |
\n400 mg thrice daily |
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\n| Acute dental infections |
\n3-7 |
\n200 mg thrice daily |
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\n| Anaerobic infections |
\n7 |
\n800 mg thrice daily and then 400 mg thrice daily |
\n7.5 mg/kg body weight thrice daily. |
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\nFor suppository : Anaerobic Infections : Adults : 1 g every 8 hours for 3 days, then 1 g every 12 hours.
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\nChildren (5 - 10 years) : 500 mg every 8 hours for 3 days, then every 12 hours, Over 10 years adult dose.
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\nSurgical Prophylaxis : Adults : 1 g 2 hours before surgery; up to 3 further doses of 1 g may be given every 8 hours for high risk procedures.
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\nChildren (5 - 10 years) : 500 mg 2 hours before surgery; up to 3 further doses of 500 mg may be given every 8 hours for high risk procedures.
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\nFor IV Infusion : Adults and children over 12 years : Infuse 500 mg 8 hourly at a rate of 5ml /minute and a maximum of 4 g should not be exceeded during a 24-hour period. For surgical prophylaxis, administration shortly before surgery should be followed by 8-hourly doses for the next 24 hours.
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\nChildren under 12 years : 7.5mg / kg body weight /day every 8 hours at a rate of 5ml / minute.
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\nTriple therapy against H. pylori infection (gastritis, peptic ulcers and gastric cancer) : Two weeks regimen : Dirozyl??(Metronidazole) 500 mg thrice daily plus Moxilin (Amoxycillin) 750 mg thrice daily plus Ranidin (Ranitidine) 300 mg at night or 150 mg twice daily.
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